Microextraction techniques combined with capillary electrophoresis in bioanalysis
نویسندگان
چکیده
منابع مشابه
Pre-Concentration Approaches Combined with Capillary Electrophoresis in Bioanalysis of Chiral Cardiovascular Drugs
Currently, there is a remarkable interest in the separation and quantification of enantiomeric compounds because of their importance in biochemistry, therapeutic drug monitoring (TDM), pharmaceutical, forensic, etc. In past decades the pharmacopoeia was governed by racemates, but nowadays the U.S. Food and Drug Administration (FDA) exclusively has been issued a statement that racemic new drugs ...
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The application of an ultraviolet (UV) light-emitting diode (LED) to on-line sample concentration/fluorescence detection in capillary electrophoresis (CE) is described. The utility of a UV-LED (peak emission wavelength at 380 nm, approximately 2 mW) for fluorescence detection was demonstrated by examining both a naturally fluorescent (riboflavin) compound and a nonfluorescent compound (tryptoph...
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Sample preparation (sample pre-treatment) is the initial step and an essential part in bioanalysis procedure. The main role of sample preparation is to extract and transfer the analyte(s) of interest from a complex matrix to a purified media such as a pure solvent for analysis and quantification. Biological fluids are complex and contain, in addition to the target analyte(s), many different unw...
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A new method of offline solid-phase microextraction coupled with capillary electrophoresis (CE) [in an uncoated capillary using borax and boric acid in acetonitrile-water (40:60) as the running buffer] with UV detection at 254 nm is presented and used for direct determination of trace biomedically important retinoic acid (RA) without any derivation. As low as 138 ng/mL RA in aqueous solution ca...
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2012
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-012-6367-y